Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in trachea-esophageal morphogenesis
Nicole A. Edwards, Scott A. Rankin, Adhish Kashyap, Alissa Warren, Zachary N. Agricola, Alan P. Kenny, Matthew J. Kofron, Yufeng Shen, Wendy K. Chung, Aaron M. Zorn
The paper shows that disruptions in endosomal trafficking of the Vangl-Celsr polarity complex cause congenital trachea-esophageal malformations in Xenopus, similar to human EA/TEF.
bioRxiv · Oct 11, 2023 · PreprintDevelopmental Biology