Matthew J. Kofron

Prenatal corticosteroid exposure disrupts immune-vascular interactions and impairs steroidogenesis in the fetal testis, revealing potentially widespread effects of a commonly used therapy.

This study identifies Foxi2 and Sox3 as master regulators of ectoderm specification in Xenopus, showing they control gene expression and epigenetic landscape through super-enhancers.

The paper identifies Gucy1α1 as a specific marker for fibroblasts in multiple organs, showing its expression increases in fibrotic conditions across mouse and human tissues.

The paper shows that disruptions in endosomal trafficking of the Vangl-Celsr polarity complex cause congenital trachea-esophageal malformations in Xenopus, similar to human EA/TEF.

This study identifies Nkx2-1-driven chromatin topology changes in alveolar epithelial progenitor cells that regulate lung regeneration and differentiation.

This study uses single-cell RNA sequencing to identify novel transcriptional signatures and epithelial-stromal interactions in acute kidney injury.

This paper identifies HH/Gli-dependent cellular mechanisms, including endosome-mediated remodeling and matrix degradation, essential for tracheoesophageal separation in mouse and Xenopus embryos.