Plakophilin-2 Coordinates Energy Metabolism and Contractility in Cardiomyocytes, Revealing Its Roles beyond Desmosomes
J. Alex Aycinena, Anley E. Tefera, Isaac Perea‐Gil, Duncan Holbrook‐Smith, Kevin J. Williams, Reva Shenwai, Farshad Farshidfar, Brendan M Ryback, Katelyn S. Foppe, Iris Wu, Aliya Zeng, Melissa Van Pell, Emma Xu, Joseph Woods, Samantha Jones, , Zhihong Jane Yang
This study identifies metabolic defects in PKP2-deficient cardiomyocytes and shows that restoring PKP2 improves contractility and electrophysiological properties.
bioRxiv · Jan 17, 2025 · PreprintCell Biology