Cell BiologybioRxivPreprint
SYNPO2L Isoforms Regulate the Action Potential Characteristics and Contractility of Atrial Cardiomyocytes via YAP Signaling to Modulate Atrial Fibrillation Risk
Rishikesan Chandrakumar, Reva Shenwai, Farshad Farshidfar…·Jonathan H. Tsui
This study shows that a rare splice mutation in SYNPO2L leads to increased SYNPO2L_B isoform expression, impairing atrial cardiomyocyte function, and that restoring SYNPO2L_A improves electrophysiology and contractility via YAP signaling.
DOI 10.1101/2025.08.03.668361