Dysregulated airway epithelial antiviral immunity in Down Syndrome impairs type III IFN response and amplifies airway inflammation during RSV infection.
Elizabeth A. Chorvinsky, Surajit Bhattacharya, Betelehem Solomon Bera, Allison Welham, Karim Ismat, Claire M. Lawlor, Diego A. Preciado, José L. Gómez, Hiroki Morizono, Dinesh K. Pillai, Maria Jimena Gutierrez, Jyoti K. Jaiswal, Gustavo Niño
This study shows that Down Syndrome impairs type III IFN response and increases proinflammatory mediators in airway epithelial cells during RSV infection, leading to severe inflammation.
American Journal of Respiratory Cell and Molecular Biology · Jun 30, 2025Peer-reviewedImmunology