Jyoti K. Jaiswal

Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne Muscular Dystrophy

This study shows that the D2-mdx mouse model exhibits juvenile-onset cardiac damage due to unresolved inflammation, and pro-resolution therapy can mitigate fibrotic degeneration.

Dysregulated airway epithelial antiviral immunity in Down Syndrome impairs type III IFN response and amplifies airway inflammation during RSV infection.

This study shows that Down Syndrome impairs type III IFN response and increases proinflammatory mediators in airway epithelial cells during RSV infection, leading to severe inflammation.

A new long-read RNA-seq analysis approach identifies and quantifies novel transcripts of very large genes

The paper introduces a long-read RNA-seq analysis approach that identifies and quantifies novel transcripts of very large genes, revealing differential exon usage and phasing across muscle types.