Hepatocyte growth factor activator inhibitor-2 rapidly inactivates airway-expressed human Type II Transmembrane Serine Proteases
Bryan J. Fraser, Ryan P. Wilson, Jackie Lac, Olzhas Ilyassov, Almagul Seitova, Yanjun Li, Ashley Hutchinson, Peter Loppnau, Maria Kutera, Gregg B. Morin, François Bénard, C.H. Arrowsmith
This study shows HAI-2 inactivates TTSPs only after zymogen activation, revealing a novel mechanism for regulating these proteases and suggesting therapeutic applications.
Journal of Biological Chemistry · Aug 12, 2026Peer-reviewedBiochemistry