Author

Olzhas Ilyassov

Structural Genomics Consortium

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Bryan J. FraseriD· 2 shared C.H. ArrowsmithiD· 2 shared François BénardiD· 2 shared Gregg B. MoriniD· 2 shared Jackie Lac· 2 shared Ryan P. Wilson· 2 shared Yanjun LiiD· 2 shared A.M. EdwardsiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Bryan J. FraserORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Hepatocyte growth factor activator inhibitor-2 rapidly inactivates airway-expressed human Type II Transmembrane Serine Proteases

Bryan J. Fraser, Ryan P. Wilson, Jackie Lac, Olzhas Ilyassov, Almagul Seitova, Yanjun Li, Ashley Hutchinson, Peter Loppnau, Maria Kutera, Gregg B. Morin, François Bénard, C.H. Arrowsmith

This study shows HAI-2 inactivates TTSPs only after zymogen activation, revealing a novel mechanism for regulating these proteases and suggesting therapeutic applications.

Journal of Biological Chemistry · Aug 12, 2026Peer-reviewedBiochemistry

Structural basis of TMPRSS11D specificity and autocleavage activation

Bryan J. Fraser, Ryan P. Wilson, Sára Ferková, Olzhas Ilyassov, Jackie Lac, Aiping Dong, Yen-Yen Li, Alma Seitova, Yanjun Li, Zahra Hejazi, Tristan M. G. Kenney, Linda Z. Penn, A.M. Edwards, Richard Leduc, Pierre‐Luc Boudreault, , C.H. Arrowsmith

The paper determines the structural basis of TMPRSS11D autocleavage activation and shows that nafamostat mesylate is cleaved by TMPRSS11D, reducing its efficacy as a protease inhibitor.

Nature Communications · May 10, 2025Peer-reviewedBiochemistry