Gregg B. Morin

The paper uses DepMap data to identify WDR89 as a genome maintenance factor through correlation analysis of genetic dependencies.

This study shows HAI-2 inactivates TTSPs only after zymogen activation, revealing a novel mechanism for regulating these proteases and suggesting therapeutic applications.

This study identifies PAN3-AS1 as an oncogenic lncRNA in AML, shows its role in chromatin organization, and demonstrates RNA-targeting LNP therapy to reduce leukemia burden.

This study uses a mouse model to identify a fibroblastic origin for DICER1 sarcomas and shows their potential to differentiate into rhabdomyoblastic or anaplastic sarcomas.

The paper identifies gene expression signatures related to neutrophil extracellular traps (NETs) in pancreatic ductal adenocarcinoma (PDAC) and shows they correlate with patient survival and metastasis, with potential therapeutic targets.

The paper identifies self-reactive intra-epithelial plasma cells in ovarian cancer that correlate with improved prognosis and suggest a mechanism for immune response against tumor heterogeneity.

The paper determines the structural basis of TMPRSS11D autocleavage activation and shows that nafamostat mesylate is cleaved by TMPRSS11D, reducing its efficacy as a protease inhibitor.

IMMUNOTAR prioritizes and identifies immunotherapeutic targets by integrating RNA-sequencing and proteomics data with public databases to evaluate surface proteins across diverse criteria.

This study demonstrates that high-flow nano-chromatography columns improve proteome analysis throughput without sacrificing data quality on standard nano-LC hardware.

RawTools extracts and analyzes data from Thermo Orbitrap raw files to aid in mass spectrometer system management and performance optimization.

This study identifies somatic coding and regulatory variants in DLBCL, revealing novel mechanisms of oncogene deregulation and potential therapeutic targets.