Long-term efficacy of adoptive cell therapy is determined by host CD8+ T cells and undermined by lymphodepleting preconditioning
Diego Figueroa, Juan Pablo Vega, Andrés Hernández-Oliveras, Felipe Gálvez-Cancino, Felipe Ardiles, Felipe Flores, Sofía Hidalgo, Ximena López, Hugo Gonzalez, Fabiola Osorio, Vincenzo Borgna, Alvaro Lladser
This study shows that host CD8+ T cells enhance adoptive cell therapy (ACT) efficacy against melanoma, while lymphodepleting preconditioning reduces long-term effectiveness by impairing host immunity.
bioRxiv · May 16, 2024 · PreprintImmunology