Author

Hugo Gonzalez

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:clinical cohort / trial· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Alastair J. Ironside· 1 shared Allison P. DrainiD· 1 shared Alvaro Lladser· 1 shared Andrés Hernández-Oliveras· 1 shared Diego FigueroaiD· 1 shared Eugene ShenderoviD· 1 shared Fabiola Osorio· 1 shared Felipe Ardiles· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Alastair J. Ironside

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2 papers

Recent·Most cited

NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer

Pavla Ticha, Jason J. Northey, Radhika Narain, Shivang Sharma, Johnathon N. Lakins, Hugo Gonzalez, Kelly Kersten, Alastair J. Ironside, Allison P. Drain, Martin Zidek, Kelvin K. Tsai, Yunn‐Yi Chen, Eugene Shenderov, Valerie Marie Weaver

This study identifies NCOR2 as an epigenetic repressor of MHC class I expression in breast cancer, promoting metastasis by inhibiting immune surveillance.

Nature Communications · May 5, 2026Peer-reviewedCancer Biology

Long-term efficacy of adoptive cell therapy is determined by host CD8+ T cells and undermined by lymphodepleting preconditioning

Diego Figueroa, Juan Pablo Vega, Andrés Hernández-Oliveras, Felipe Gálvez-Cancino, Felipe Ardiles, Felipe Flores, Sofía Hidalgo, Ximena López, Hugo Gonzalez, Fabiola Osorio, Vincenzo Borgna, Alvaro Lladser

This study shows that host CD8+ T cells enhance adoptive cell therapy (ACT) efficacy against melanoma, while lymphodepleting preconditioning reduces long-term effectiveness by impairing host immunity.

bioRxiv · May 16, 2024 · PreprintImmunology