Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent
Alannah Lejeune, Chunyi Zhou, Defne Ercelen, Gregory Putzel, Xiaomin Yao, Alyson R Guy, Miranda B. Pawline, Magdalena M Podkowik, Alejandro Pironti, Victor J. Torres, Bo Shopsin, Ken Cadwell
This study shows female mice clear MRSA from the gut faster than males, relying on gut microbiota and Th17 cells, while ovariectomy reduces this resistance.
bioRxiv · Jul 17, 2024Immunology