An Optimized RNF126-Targeting Covalent Handle for Molecular Glue Degraders
Aman Modi, Ethan S. Toriki, Christian E. Stieger, Emily A. Lau, Claire Song, Alyssa J. Chew, Amy C. Tsao, Kaila Nishikawa, Jeffrey M. McKenna, Daniel K. Nomura
This paper develops an optimized covalent handle targeting RNF126 to create molecular glue degraders, showing improved selectivity and reduced cytotoxicity compared to a fumarate-based handle.
Bioorganic & Medicinal Chemistry Letters · Jul 24, 2026Peer-reviewedBiochemistry