Christian E. Stieger

This paper develops an optimized covalent handle targeting RNF126 to create molecular glue degraders, showing improved selectivity and reduced cytotoxicity compared to a fumarate-based handle.

This paper introduces TRACERs, small-molecule drugs that silence transcription factors in cancer by recruiting repressor complexes, showing efficacy against ER and AR in breast and prostate cancer.

This paper introduces covalent activity-based probes to study phosphoarginine phosphatases, identifying new enzymes and expanding understanding of bacterial signal transduction.

This paper identifies a sulfinyl aziridine compound that selectively degrades MYC by targeting specific residues in its intrinsically disordered regions, demonstrating the potential of chiral small molecules for targeting undruggable proteins.

This study identifies oligophosphorylation as a new phosphorylation mode, showing NME1 can catalyze its own oligophosphorylation using ATP, with implications for phosphoregulation.

This study identifies SFiNX, a complex required for Piwi-mediated co-transcriptional silencing in Drosophila, revealing its role in piRNA-guided heterochromatin formation.

This paper summarizes current XL-MS practices, compares strategies, and proposes common protocols to establish best practice guidelines for accurate and reproducible results.