Kaila Nishikawa

This paper develops an optimized covalent handle targeting RNF126 to create molecular glue degraders, showing improved selectivity and reduced cytotoxicity compared to a fumarate-based handle.

This study identifies a dietary lipid axis driven by linoleic acid and FADS2 that suppresses antitumor immunity in liver cancer, offering a therapeutic target for immunotherapy resistance.

This study identifies mRNA glycation by methylglyoxal as a metabolic stress sensor, showing impaired translation and beta-cell dysfunction, which is mitigated by metformin.