The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines
Prasanth Viswanathan, Justine R Bersonda, Jackson Gill, Alyssandra Navarro, Allison C. Farrar, Thomas Caldarera, Andrew Murphy, Daniel Dunham, Karl W. Boehme, Mark Manzano
This study identifies a genetic interaction between MCL1 and MARCHF5 in PEL cells, showing that MARCHF5 promotes cell survival by degrading NOXA, an antagonist of MCL1.
PLoS Pathogens · Oct 1, 2026Peer-reviewedCancer Biology