Female Specific Restrictive Cardiomyopathy and Metabolic Dysregulation in transgenic mice expressing a Peptide of the Amino-Terminus of GRK2
Kamila M. Bledzka, Iyad H. Manaserh, Amanda Ifft, Julie H. Rennison, Madison Bohacek, Katie M. Vasiliauskas, Jessica Grondolsky, Isaac Ampong, David R. Van Wagoner, Sarah M. Schumacher
This study shows that female mice with cardiac-restricted GRK2 amino-terminal peptide expression develop restrictive cardiomyopathy and metabolic dysregulation under pressure overload, unlike males.
bioRxiv · Oct 14, 2024 · PreprintPhysiology