Synonymous codon usage regulates translation initiation
Chloe L. Barrington, Gabriel Galindo, Amanda Lynn Koch, Emma R. Horton, Evan J. Morrison, Samantha Tisa, Timothy J. Stasevich, Olivia S. Rissland
The paper shows that nonoptimal codon usage represses translation initiation, reducing protein levels independently of transcript abundance or stability.
Cell Reports · Dec 1, 2023Peer-reviewedMolecular Biology