Targeting Ogt in ADPKD mitigates metabolic reprogramming and renal cystogenesis, extending survival
Matthew A. Kavanaugh, Saleem Ahmad, Dona Greta Isai, Heather A. Riddle, Amanda P. Assis, Chadhve Ranganathan, Aakriti Chaturvedi, Vincent Lam, Nikhitha Muthineni, R. Abid, Jenna E. Jurgensmeyer, Casey Blades, Michele T. Pritchard, Madhulika Sharma, Darren P. Wallace, , Pamela Vivian Tran
This study shows that targeting Ogt in ADPKD reduces cyst formation and extends survival by normalizing metabolic pathways and preserving cellular energy production.
bioRxiv · Dec 16, 2025 · PreprintCell Biology