Michele T. Pritchard

Age-dependent dysregulated post-ovulatory debris clearance promotes ovarian fibroinflammation

This study shows that impaired post-ovulatory debris clearance in aged ovaries leads to persistent corpus luteum accumulation and fibroinflammation.

Self-organizing ovarian somatic organoids preserve cellular heterogeneity and reveal cellular contributions to ovarian aging

This study develops ovarian somatic organoids that maintain cellular diversity and reveal age-related changes in cellular composition and function.

Targeting Ogt in ADPKD mitigates metabolic reprogramming and renal cystogenesis, extending survival

This study shows that targeting Ogt in ADPKD reduces cyst formation and extends survival by normalizing metabolic pathways and preserving cellular energy production.

Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures

This study identifies multinucleated giant cells (MNGCs) in aging ovaries, showing their unique immune and degradation-related molecular signatures through transcriptomic and imaging analyses.

Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse

This study shows that systemic Pirfenidone treatment reduces ovarian fibrosis and improves ovarian function in aged mice by modulating the fibro-inflammatory microenvironment.

Intraflagellar transport-A deficiency attenuates ADPKD in a renal tubular- and maturation-dependent manner

This study shows that deleting the IFT-A gene Thm1 in ADPKD mouse models has development-specific effects on kidney cysts, inflammation, and cilia length, suggesting environmental factors influence ciliary homeostasis and disease progression.

IFT-A deficiency in juvenile mice impairs biliary development and exacerbates ADPKD liver disease

This study shows that Thm1 deletion in juvenile Pkd2 mice worsens biliary development and PLD, while adult Thm1 deletion has no effect, highlighting distinct roles of IFT-A and IFT-B in liver disease.