Madhulika Sharma

This study shows that targeting Ogt in ADPKD reduces cyst formation and extends survival by normalizing metabolic pathways and preserving cellular energy production.

This study shows that Notch3 deletion reduces HIV-1 gene expression and systemic inflammation, improving outcomes in HIV-associated chronic kidney disease.

This study shows that deleting the IFT-A gene Thm1 in ADPKD mouse models has development-specific effects on kidney cysts, inflammation, and cilia length, suggesting environmental factors influence ciliary homeostasis and disease progression.

This study shows that Thm1 deletion in juvenile Pkd2 mice worsens biliary development and PLD, while adult Thm1 deletion has no effect, highlighting distinct roles of IFT-A and IFT-B in liver disease.

This study shows Quinomycin A reduces cyst progression in PKD by inhibiting Notch signaling and normalizing cilia lengths in a mouse model and human cells.