Author

Roger Lawrence

BioMarin (United States)ORCID 0000-0002-5027-2579Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Organism:human· 1 Organism:rat· 1

Frequent Co-Authors

Ahlam N. QerqeziD· 1 shared Amanda R. Luu· 1 shared Anastasia G. HenryiD· 1 shared Ann Hong NguyeniD· 1 shared Annie ArguelloiD· 1 shared Brett E. CrawfordiD· 1 shared Bryan K. Yip· 1 shared Cathal S. MahoniD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

Ahlam N. QerqezORCID

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2 papers

Recent·Most cited

A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction

Oliver B. Davis, Jennifer E. Kung, Sonnet S. Davis, Rajarshi Ghosh, Shan V. Andrews, Neal S. Gould, Jillian H. Kluss, Elliot R. Thomsen, Maayan R. Agam, John P. Coan, Michael T. Maloney, Ann Hong Nguyen, Hoang Ngan Nguyen, Nicholas E. Propson, Edwin I. Lozano, , Anastasia G. Henry

This study shows the PD-risk GBA1 variant E326K reduces lysosomal GCase activity by disrupting LIMP2 interaction and causes lysosomal and mitochondrial dysfunction.

bioRxiv · Aug 28, 2025 · PreprintCell Biology

BMN 250, a fusion of lysosomal alpha-N-acetylglucosaminidase with IGF2, exhibits different patterns of cellular uptake into critical cell types of Sanfilippo syndrome B disease pathogenesis.

Gouri Yogalingam, Amanda R. Luu, Heather Prill, Melanie J. Lo, Bryan K. Yip, John Holtzinger, Terri Christianson, Mika Aoyagi-Scharber, Roger Lawrence, Brett E. Crawford, Jonathan H. LeBowitz

This study characterizes two distinct cellular uptake mechanisms for BMN 250 in Sanfilippo B disease, showing CI-MPR-mediated uptake in neurons and astrocytes and receptor-independent uptake in microglia.

PLoS ONE · Jan 18, 2019Peer-reviewedGenetics