Klf4-dependent pivotal role of smooth muscle-derived Gli1+ lineage progenitor cells in lung cancer progression
Sizhao Lu, Andre Navarro, Amber M. Johnson, Tysen Noble, Austin Jolly, Allison Dubner, Karen S. Moulton, Raphael A. Nemenoff, Mary C. M. Weiser-Evans
This study identifies AdvSca1-SM cells as a key component of lung tumors and shows that Klf4-dependent regulation of these cells affects cancer progression and immunotherapy response.
bioRxiv · May 30, 2025 · PreprintCancer Biology