Raphael A. Nemenoff

This study shows that KLF4 in smooth muscle cell-derived progenitor cells drives AngII-induced cardiac inflammation and fibrosis by promoting a profibrotic phenotype.

This study shows that NTRK inhibitors can reduce brain metastases in lung cancers with wild-type NTRK, even without NTRK fusions.

This study models acquired resistance to RET inhibitors in murine lung cancer and identifies combination therapies that improve treatment outcomes.

This study shows that DTP cells in EGFR-mutant lung cancer drive immunosuppression through YAP/TEAD activity, and co-targeting YAP/TEAD improves EGFR TKI therapy efficacy.

This study identifies AdvSca1-SM cells as a key component of lung tumors and shows that Klf4-dependent regulation of these cells affects cancer progression and immunotherapy response.

This study investigates how aging-related inflammation contributes to lung cancer development by analyzing gene expression data and using mouse models to assess the role of inflammation in oncogenesis.

This study shows that IDO1 inhibition reduces ADPKD severity by altering the cystic immune microenvironment.