Small RNA-mediated genomic silencing promotes telomere stability in the absence of telomerase in C. elegans
Lu Lu, Ambika Bhattarai, Charlie Longtine, Stephen Frenk, Madelyn Garrison, Julie Seohyun Lee, Evan Lister-Shimauchi, Shawn Cameron Ahmed
The paper shows that small RNA-mediated genomic silencing maintains telomere stability in C. elegans without telomerase by promoting heterochromatin formation and subtelomeric small RNA biogenesis.
bioRxiv · May 19, 2026 · PreprintGenetics