Lu Lu

BXD51: A Robust and Translational Mouse Model for Studying the Pathophysiology of Glaucoma

This study characterizes the BXD51 mouse strain as a reproducible model of chronic progressive glaucoma, showing distinct clinical and structural features compared to other strains.

Comparison of Deep Learning Tools for Optic Nerve Axon Quantification Finds Limited Generalizability on Independent Validation

This study evaluates three deep learning models for optic nerve axon quantification on a novel rat dataset, finding reduced performance compared to published benchmarks.

Small RNA-mediated genomic silencing promotes telomere stability in the absence of telomerase in C. elegans

The paper shows that small RNA-mediated genomic silencing maintains telomere stability in C. elegans without telomerase by promoting heterochromatin formation and subtelomeric small RNA biogenesis.

Genetic Modulation of Lifespan: Dynamic Effects, Sex Differences, and Body Weight Trade-offs

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

Integrated single-cell and bulk transcriptomic analysis leverages liver metastasis-related genes to develop a prognostic model for colorectal cancer patients

The paper identifies prognostic genes from liver metastasis-related differences in colorectal cancer and develops a scoring system to predict patient outcomes.

MONICA: A Web Application for Automated Whole Optic Nerve Contour Extraction and Morphometric Analysis Validated Across Taxonomic Orders and Image Quality Levels

MONICA is a web-based tool that automatically extracts optic nerve boundaries and calculates morphometric metrics, validated across species and image qualities.

The Pgb1 locus controls glycogen aggregation in astrocytes of the aged hippocampus without impacting cognitive function

The paper identifies the Pgb1 locus as controlling glycogen aggregation in aged hippocampal astrocytes without affecting cognitive function.

Human RNase 2 is essential for macrophage response to viral RNA

This study shows RNase 2 is essential for macrophage antiviral response and homeostasis, with loss of RNase 2 leading to stress response and impaired antiviral immunity.

A Conserved Mycobacterial Nucleomodulin Hijacks the Host COMPASS Complex to Reprogram Pro-Inflammatory Transcription and Promote Intracellular Survival

This study identifies MgdE, a mycobacterial nucleomodulin, as a protein that targets the host COMPASS complex to suppress pro-inflammatory gene transcription and enhance bacterial survival.

Genomic and Genetic Insights into Mendel's Pea Genes

This study identifies genetic variants underlying seven Mendelian traits in pea, revealing new alleles and gene mutations for traits previously poorly understood.

A genome-wide association study of neonatal metabolites

This study identifies 13 novel genetic associations and confirms 17 existing ones between SNPs and neonatal metabolites using genome-wide association analysis of maternal low-pass genomes.

YmoA functions as a molecular stress sensor in Yersinia

This study identifies YmoA as a molecular stress sensor in Yersinia that adjusts virulence gene expression in response to temperature and osmolarity changes.

Male gonad-enriched microRNAs function to control sperm production in C. elegans

The paper identifies male gonad-enriched microRNAs in C. elegans that regulate sperm production and fecundity through functional analysis and small RNA sequencing.

Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping

The paper uses linked-read whole-genome sequencing to identify DNA variants in BXD mice and maps them to phenotypes, enabling systems genetics and precision medicine.