Retinal network dysfunction precedes structural degeneration in severe GUCA1A cone-rod dystrophy
Anna Avesani, Giuditta Dal Cortivo, Sabrina Asteriti, Giorgia Targa, Laura Veschetti, Valerio Marino, Amedeo Biasi, Carmen Longo, Barbara Cisterna, Karolina Saran, Giovanni Malerba, Andrzej T. Foik, Marco Cambiaghi, Lorenzo Cangiano, Daniele Dell’Orco
This study shows that retinal network dysfunction occurs before structural degeneration in severe GUCA1A cone-rod dystrophy, suggesting an early therapeutic window.
bioRxiv · Jul 3, 2026 · PreprintNeuroscience