Integrated Stress Response and Necroptosis Drive Epithelial Dysfunction in Crohn's Disease: Repurposing Cancer drugs for Permeability Barrier Healing.
Debasish Halder, Ritwika Biswas Lanford, Amin Ghazi, Jason Ken Hou, Yaohong Wang, Seema Khurana
This study identifies ISR activation and RIPK3-mediated necroptosis as drivers of epithelial dysfunction in CD and shows that repurposed cancer drugs restore barrier function and regeneration.
Gastro Hep Advances · Jan 1, 2026Peer-reviewedPathology