Author

Yaohong Wang

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-5088-1673Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pathology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Debasish HalderiD· 2 shared Jason Ken HouiD· 2 shared Seema KhuranaiD· 2 shared Amin Esmaeilniakooshkghazi· 1 shared Amin Ghazi· 1 shared Charles Chuanhai GuoiD· 1 shared Chenxuan ZangiD· 1 shared Chiranjeevi Padala· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPathology

Debasish HalderORCID

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3 papers

Recent·Most cited

BioinformaticsPLoS Computational BiologyPeer-reviewedMar 17, 2026

TUSCAN: Tumor segmentation and classification analysis in spatial transcriptomics

Chenxuan Zang, Charles Chuanhai Guo, Yaohong Wang…·Z G Li

TUSCAN improves tumor region identification in spatial transcriptomics by integrating copy number variation profiles with histopathological images.

3 citationstop 4%

humanspatial transcriptomics

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PathologyGastro Hep AdvancesPeer-reviewedJan 1, 2026

Integrated Stress Response and Necroptosis Drive Epithelial Dysfunction in Crohn's Disease: Repurposing Cancer drugs for Permeability Barrier Healing.

Debasish Halder, Ritwika Biswas Lanford, Amin Ghazi…·Seema Khurana

This study identifies ISR activation and RIPK3-mediated necroptosis as drivers of epithelial dysfunction in CD and shows that repurposed cancer drugs restore barrier function and regeneration.

DOI 10.1016/j.gastha.2026.100950

mousebulk RNA-seq

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PathologybioRxivPreprintOct 27, 2025

Coordinated HNF4α and HNF4γ Suppression Defines a Reversible Ileal Epithelial Barrier Defect in Crohn,s Disease

Debasish Halder, Amin Esmaeilniakooshkghazi, Chiranjeevi Padala…·Seema Khurana

This study identifies coordinated suppression of HNF4α and HNF4γ as an epithelial-intrinsic barrier defect in ileal Crohn's disease, reversible with HNF4 agonists.

1 citation

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