Author

Debasish Halder

University of HoustonORCID 0009-0002-0303-3839Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Jason Ken HouiD· 2 shared Seema KhuranaiD· 2 shared Yaohong WangiD· 2 shared Amin Esmaeilniakooshkghazi· 1 shared Amin Ghazi· 1 shared Chiranjeevi Padala· 1 shared Lei CheniD· 1 shared Michael Paul VerziiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPathology

Jason Ken HouORCID

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2 papers

Recent·Most cited

PathologyGastro Hep AdvancesPeer-reviewedJan 1, 2026

Integrated Stress Response and Necroptosis Drive Epithelial Dysfunction in Crohn's Disease: Repurposing Cancer drugs for Permeability Barrier Healing.

Debasish Halder, Ritwika Biswas Lanford, Amin Ghazi…·Seema Khurana

This study identifies ISR activation and RIPK3-mediated necroptosis as drivers of epithelial dysfunction in CD and shows that repurposed cancer drugs restore barrier function and regeneration.

DOI 10.1016/j.gastha.2026.100950

mousebulk RNA-seq

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PathologybioRxivPreprintOct 27, 2025

Coordinated HNF4α and HNF4γ Suppression Defines a Reversible Ileal Epithelial Barrier Defect in Crohn,s Disease

Debasish Halder, Amin Esmaeilniakooshkghazi, Chiranjeevi Padala…·Seema Khurana

This study identifies coordinated suppression of HNF4α and HNF4γ as an epithelial-intrinsic barrier defect in ileal Crohn's disease, reversible with HNF4 agonists.

1 citation

mousehuman

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