Author

Seema Khurana

University of HoustonORCID 0000-0002-6884-810XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Debasish HalderiD· 2 shared Jason Ken HouiD· 2 shared Yaohong WangiD· 2 shared Amin Esmaeilniakooshkghazi· 1 shared Amin Ghazi· 1 shared Chiranjeevi Padala· 1 shared Lei CheniD· 1 shared Michael Paul VerziiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPathology

Debasish HalderORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Integrated Stress Response and Necroptosis Drive Epithelial Dysfunction in Crohn's Disease: Repurposing Cancer drugs for Permeability Barrier Healing.

Debasish Halder, Ritwika Biswas Lanford, Amin Ghazi, Jason Ken Hou, Yaohong Wang, Seema Khurana

This study identifies ISR activation and RIPK3-mediated necroptosis as drivers of epithelial dysfunction in CD and shows that repurposed cancer drugs restore barrier function and regeneration.

Gastro Hep Advances · Jan 1, 2026Peer-reviewedPathology

Coordinated HNF4α and HNF4γ Suppression Defines a Reversible Ileal Epithelial Barrier Defect in Crohn,s Disease

Debasish Halder, Amin Esmaeilniakooshkghazi, Chiranjeevi Padala, Yaohong Wang, Jason Ken Hou, Xia Qiu, Lei Chen, Michael Paul Verzi, Seema Khurana

This study identifies coordinated suppression of HNF4α and HNF4γ as an epithelial-intrinsic barrier defect in ileal Crohn's disease, reversible with HNF4 agonists.

bioRxiv · Oct 27, 2025 · PreprintPathology