The gut microbiome and its metabolites are necessary for morphine reward
Rebecca S. Hofford, Nicholas L. Mervosh, Tanner J. Euston, Katherine R. Meckel, Amon T. Orr, Drew D. Kiraly
This study shows that gut microbiome depletion reduces morphine reward and that short-chain fatty acids mediate this effect through changes in nucleus accumbens gene expression.
bioRxiv · Sep 17, 2020 · PreprintNeuroscience