Rebecca S. Hofford

Granulocyte colony-stimulating factor acts through calcium-permeable AMPA receptors to potentiate cocaine reward

This study shows that G-CSF enhances cocaine reward by promoting glutamatergic synaptic remodeling in the nucleus accumbens through calcium-permeable AMPA receptors.

Brief disruption of the microbiome has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice

This study shows that disrupting the microbiome affects morphine reward and gene expression in the medial prefrontal cortex differently in adolescent and adult mice.

Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking

This study shows that gut microbiome depletion increases cocaine-seeking behavior in rats, which can be reversed by replenishing short-chain fatty acids.

Changes in gut microbiome composition drive fentanyl intake and striatal proteomic changes

This study shows that changes in gut microbiome composition influence fentanyl intake and striatal proteomic changes in a drug self-administration model.

Dietary polyphenols drive alterations in behavior, transcriptional regulation, and commensal microbiota in models of opioid use.

This study shows dietary polyphenols alter behavior, gene expression, and microbiota in response to morphine, with dose-dependent effects.

Granulocyte-Colony Stimulating Factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex

This study shows that G-CSF reduces cocaine-seeking behavior and alters glutamatergic synaptic proteins in the medial prefrontal cortex.

The gut microbiome and its metabolites are necessary for morphine reward

This study shows that gut microbiome depletion reduces morphine reward and that short-chain fatty acids mediate this effect through changes in nucleus accumbens gene expression.