Drew D. Kiraly

This study shows that G-CSF enhances cocaine reward by promoting glutamatergic synaptic remodeling in the nucleus accumbens through calcium-permeable AMPA receptors.

The paper examines how chronic alcohol drinking affects the relationship between gene expression and dopamine regulation in the brain, finding persistent functional changes despite no change in transcript levels.

This study shows that disrupting the microbiome affects morphine reward and gene expression in the medial prefrontal cortex differently in adolescent and adult mice.

This study shows that synaptogyrin-3 reduces cocaine self-administration and prevents dopamine deficits by enhancing dopamine signaling and cognitive flexibility in rats.

The paper shows acetate supplementation improves social deficits and changes gene expression in the prefrontal cortex of Shank3-deficient mice.

This study shows that gut microbiome depletion increases cocaine-seeking behavior in rats, which can be reversed by replenishing short-chain fatty acids.

This study shows that changes in gut microbiome composition influence fentanyl intake and striatal proteomic changes in a drug self-administration model.

This study shows dietary polyphenols alter behavior, gene expression, and microbiota in response to morphine, with dose-dependent effects.

This study shows that G-CSF enhances cocaine-induced dopamine release in the nucleus accumbens through a direct mechanism, independent of dopamine transporter function.

This study shows that G-CSF reduces cocaine-seeking behavior and alters glutamatergic synaptic proteins in the medial prefrontal cortex.

This study shows that gut microbiome depletion reduces morphine reward and that short-chain fatty acids mediate this effect through changes in nucleus accumbens gene expression.

The paper analyzes multi-omic data from stressed mice to identify molecular disruptions linked to depression and shows antidepressants reverse these changes in specific brain regions.