C5aR1 inhibition alleviates cranial radiation-induced cognitive decline
Robert P. Krattli, An H. Do, Sanad M. El-Khatib, Leila Alikhani, Mineh Markarian, Arya R. Vagadia, Manal T. Usmani, Shreya Madan, Janet E. Baulch, Richard J. Clark, Trent M. Woodruff, Andrea J. Tenner, Munjal M. Acharya
This study shows that inhibiting C5aR1 reduces radiation-induced cognitive decline in mice, improving memory and reducing neuroinflammation without affecting tumor treatment.
Cancer Research · Oct 14, 2025Peer-reviewedNeuroscience