Richard J. Clark

This study designs C5aR1-selective peptide agonists using structure-guided computational methods and experimental validation, showing improved selectivity and stability through specific amino acid substitutions.

This paper identifies naturally-encoded signaling bias at C5aR1 and C5aR2 receptors through structural and functional analyses, revealing molecular mechanisms underlying biased signaling in GPCRs.

This study shows that an AGE-rich diet during adolescence impairs memory via hippocampal synaptic deficits and microbiome changes, which can be mitigated by AGE inhibitors.

This study shows that inhibiting C5aR1 reduces radiation-induced cognitive decline in mice, improving memory and reducing neuroinflammation without affecting tumor treatment.

This study identifies a convergent molecular mechanism and species-specific pharmacology in complement anaphylatoxin receptors through structural and functional analyses of ligand-receptor interactions.