Munjal M. Acharya

This study uses spatial transcriptomics to show that immune checkpoint inhibitors activate microglia via T cell interactions, leading to neuroinflammation and synaptic dysfunction in the brain.

This study shows that inhibiting C5aR1 reduces radiation-induced cognitive decline in mice, improving memory and reducing neuroinflammation without affecting tumor treatment.

This study investigates the role of Dynamin-1 in cancer-related cognitive impairment using human and animal models, finding that DNM1 downregulation is associated with cognitive impairment onset.

This study shows that myeloid-derived β-hexosaminidase supports neuronal lysosomal function and that microglial replacement can reverse Sandhoff disease symptoms.

This study shows that riluzole improves cognitive function and reduces neurodegeneration in mice after cranial radiation therapy by increasing BDNF levels and reducing neuroinflammation.

This study shows that combination immune checkpoint inhibition disrupts CNS neuro-immune homeostasis, activates microglia, and causes long-term cognitive impairments in a murine melanoma model.