Sanad M. El-Khatib

C5aR1 inhibition alleviates cranial radiation-induced cognitive decline

This study shows that inhibiting C5aR1 reduces radiation-induced cognitive decline in mice, improving memory and reducing neuroinflammation without affecting tumor treatment.

Myeloid-derived β-hexosaminidase is essential for neuronal health and lysosome function: implications for Sandhoff disease

This study shows that myeloid-derived β-hexosaminidase supports neuronal lysosomal function and that microglial replacement can reverse Sandhoff disease symptoms.

BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences

This study shows that riluzole improves cognitive function and reduces neurodegeneration in mice after cranial radiation therapy by increasing BDNF levels and reducing neuroinflammation.

Immune Checkpoint Inhibition-related Neuroinflammation Disrupts Cognitive Function

This study shows that combination immune checkpoint inhibition disrupts CNS neuro-immune homeostasis, activates microglia, and causes long-term cognitive impairments in a murine melanoma model.