Mgl2+ cDC2 triggering of fungal allergic inflammation depends on a spore induced glycolytic shift fuelled by local availability of glucose
Julio Furlong-Silva, George Vere, Phuong Tuyen Nguyen, Nigel Gotts, Yun Xu A, Stefano A. P. Colombo, Daniel P. Conn, Bethany L. McCann, Ana Cruz, Laila Alsharq, Craig Beall, Rafael José Argüello, Shizuo Akira, Selinda J. Orr, Salomé LeibundGut‐Landmann, , Peter C. Cook
This study shows that Mgl2+ cDC2s trigger fungal allergic inflammation through a glycolytic shift driven by glucose availability after spore uptake.
bioRxiv · Jul 13, 2025 · PreprintImmunology