Elaine Bignell

This paper develops a Bayesian mechanistic model to infer antifungal drug synergy and drug-action kinetics from optical density data of Candidozyma auris.

This study uses live-cell imaging to analyze real-time responses of fungal hyphae to antifungals, revealing differences in drug efficacy between Aspergillus fumigatus and Candida albicans.

The paper examines host-pathogen interactions between Candida albicans and Lactobacillus isolates in a vaginal epithelial model, showing divergent effects on cytotoxicity and pH.

This study shows that Mgl2+ cDC2s trigger fungal allergic inflammation through a glycolytic shift driven by glucose availability after spore uptake.

The paper identifies genes involved in sulfur metabolism in Aspergillus fumigatus during infection, highlighting ShmB as a promising antifungal target due to its essential role in virulence and structural differences from the human enzyme.

This paper proposes a mathematical model to estimate morphology-specific fungal growth rates from optical density data, improving accuracy over existing methods.