Andrew S. MacDonald

This study shows macrophages enhance collagen deposition in fibroblasts through circadian regulation, with M2 macrophages using PDGFA to strengthen circadian rhythms and increase collagen production.

This study identifies conventional dendritic cells type 1 (cDC1s) as critical for anti-tumor immunity in brain metastases, showing their unique role in promoting CD8+ T cell responses and enhancing immunotherapy efficacy.

This study shows that Trypanosoma brucei infection affects the uterine immune environment and causes neuroendocrine dysfunction in mice, with distinct effects on morphology and inflammation.

This study identifies BATF3 as a critical regulator of innate-like γδ T cell homeostasis, function, and tissue distribution, revealing its role in survival, IL-17 production, and immune responses.

The paper shows that IgE memory responses are confined to lymphoid organs through GC IL-4 microniches, which are critical for IgE production during allergen recall.

A cytochrome P450 humanised mouse model is used to study Schistosoma mansoni development, schistosomiasis, drug metabolism and drug efficacy.

This study shows that Mgl2+ cDC2s trigger fungal allergic inflammation through a glycolytic shift driven by glucose availability after spore uptake.

The paper assesses genetic diversity of soil-transmitted helminths across regions and evaluates its impact on molecular diagnostic targets using low-coverage genome sequencing and in vitro assays.

This study investigates how pulmonary macrophage subsets respond metabolically to polarizing stimuli in vivo, revealing distinct metabolic profiles between alveolar and interstitial macrophages.

This study shows that SOX9 is critical for maintaining granuloma structure and ECM barrier formation in schistosomiasis, which protects the liver from damage.

This study identifies hallmark gene expression and metabolic profiles of type 2 activated human lung macrophages using primary tissue-derived cells.