Darius P. H. Armstrong-James

Mycobacterial lipoarabinomannan negatively interferes with macrophage responses to Aspergillus fumigatus in-vitro

This study shows that mycobacterial lipoarabinomannan impairs macrophage ability to kill Aspergillus fumigatus conidia and increases inflammatory cytokine release in vitro.

Antarctic marine microplastics reveals environmental persistence and rapid evolution of Candida auris

The paper isolates Candida auris from Antarctica, identifies cold-adapted traits, and links mutator phenotypes to rapid evolution and drug resistance in global C. auris clades.

Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease

This study identifies IL-1RAP as a target for reducing eosinophilia in allergic fungal airway disease using a mouse model of chronic A. fumigatus exposure.

Mgl2+ cDC2 triggering of fungal allergic inflammation depends on a spore induced glycolytic shift fuelled by local availability of glucose

This study shows that Mgl2+ cDC2s trigger fungal allergic inflammation through a glycolytic shift driven by glucose availability after spore uptake.

Increased NFAT and NFκB signalling contribute to the hyperinflammatory phenotype in response to Aspergillus fumigatus in cystic fibrosis

This study shows that CFTR deficiency increases NFAT and NFκB signaling in response to Aspergillus fumigatus, leading to hyperinflammation and reduced fungal control in cystic fibrosis.

Precision-cut lung slices in air-liquid interface (PCLS-ALI): A novel ex-vivo model for the study of Pulmonary Aspergillosis

The paper introduces a novel ex-vivo model using precision-cut lung slices in air-liquid interface to study Pulmonary Aspergillosis and assess antifungal treatments.

Genomic epidemiology of Candida auris introduction and outbreaks in the United Kingdom

This study uses genomic data to trace the introduction and transmission of Candida auris in the UK between 2014 and 2019, identifying at least three introductions and multiple transmission events.

Tracing patterns of evolution and acquisition of drug resistant Aspergillus fumigatus infection from the environment using population genomics

The paper uses population genomics to trace the evolution and environmental acquisition of drug-resistant Aspergillus fumigatus, finding evidence of resistant isolates transmitted from the environment to patients.