14-3-3 Enables β-Adrenergic Regulation of the Cardiac Sodium Channel at the Intercalated Disc
Yang Zheng, Ana Laura López Serrano, Snizhana Chorna, Xiaoping Wan, Rupam Biswas, Angelina Ramirez‐Navarro, Krishna Chinthalapudi, Seth H. Weinberg, Gea‐Ny Tseng, Isabelle Deschênes
This study identifies 14-3-3 and S460 as critical for beta-adrenergic regulation of Nav1.5 at the cardiac intercalated disc, enhancing conduction velocity under sympathetic stimulation.
bioRxiv · Oct 26, 2026 · PreprintMolecular Biology