Adaptive thermogenesis reprograms the behavioural and metabolic responses to protein restriction for successful amino acid homeostasis
Anthony H. K. Tsang, Simon Benoit, Sam M. Lockhart, Ana Parish, Sam Virtue, Lorena da Silva Paes, Xue Li Wong, Debra Remmington, Antonio Vidal‐Puig, Stephen O’Rahilly, Anthony P. Coll, Valentina Pirro, Albert Koulman, Clémence Blouet
This study shows that mice adjust their behavior and metabolism in response to protein restriction, with temperature affecting amino acid homeostasis and metabolic adaptations.
bioRxiv · Jul 30, 2025 · PreprintPhysiology