Sam M. Lockhart

This study uses genetic data to show that HMGCR inhibition affects coronary artery disease and type 2 diabetes through different causal pathways, with BMI and LDL-C playing distinct roles.

This study shows that mice adjust their behavior and metabolism in response to protein restriction, with temperature affecting amino acid homeostasis and metabolic adaptations.

This study uses population-scale whole genome sequencing to identify novel rare protein-coding variants associated with cardiometabolic traits, revealing new biological mechanisms and gene functions.

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.

The paper uses antibody-based proteomics to identify disease-causing genes and proteins by analyzing plasma proteome data from 1,180 individuals, finding new gene-protein-disease links and improving causal gene assignment in GWAS loci.

This study uses Mendelian randomization to examine if ACE inhibitors or cardiometabolic risk factors affect lung ACE2 and TMPRSS2 expression or plasma ACE2 levels, finding no overall association.