Sam Virtue

This study shows that mice adjust their behavior and metabolism in response to protein restriction, with temperature affecting amino acid homeostasis and metabolic adaptations.

This study creates a mouse model of SHORT syndrome by introducing a Pik3r1 mutation, revealing lipodystrophic insulin resistance without dyslipidemia.

This study shows mTORC1 in AGRP neurons integrates food-related cues to control iBAT thermogenesis in mice, linking energy availability to adaptive energy expenditure.