Transient CB2 receptor activation triggers irreversible luminal differentiation via chromatin remodeling in breast cancer
Nuria G. Martínez-Illescas, Gemma Pérez-García, María Rubert-Hernández, Camila Quezada-Gutiérrez, Estrella Martín-Zapater, Luis Miguel Alonso‐Colmenar, Carmen Hernández, Ángela Zarco-Cuadrillero, Eduardo Caleiras, Miguel Muñoz‐Ruiz, Ana Payo-Payo, Laura Frías, Cristina Sánchez, Mercedes Balcells, Elazer Reuven Edelman, María Salazar‐Roa
The paper shows that transient CB2R activation in breast cancer cells leads to irreversible luminal differentiation through chromatin remodeling, enhancing tamoxifen response and reducing resistance.
bioRxiv · Jul 29, 2025 · PreprintCancer Biology