Probiotic neoantigen delivery vectors for precision cancer immunotherapy
Andrew Redenti, Jongwon Im, Benjamin J. Redenti, Fangda Li, Mathieu Rouanne, Zeren Sheng, William Y. Sun, Candice R. Gurbatri, Shunyu Huang, Meghna Komaranchath, YoungUk Jang, Jaeseung Hahn, Edward R. Ballister, Rosa L. Vincent, Ana Vardoshivilli, , Nicholas Arpaia
This study engineers probiotic E. coli to deliver neoantigen peptides, enhancing T cell immunity and reducing tumor growth in mice.
Nature · Oct 16, 2024Peer-reviewedSynthetic Biology