William Y. Sun

This study uses single-cell RNA-seq to analyze X-ray irradiation effects on Drosophila wing discs, revealing regional and intra-regional gene expression heterogeneity.

This study identifies HIF2-driven PTHrP as a cause of cachexia and hypercalcemia in kidney cancer and shows that HIF2 inhibitors can alleviate these symptoms.

This paper describes engineered bacteria that deliver a viral genome to initiate oncolytic infection in tumors, demonstrating bacterial control over viral replication.

This study engineers probiotic E. coli to deliver neoantigen peptides, enhancing T cell immunity and reducing tumor growth in mice.

This study identifies Echinoid's dual role in promoting tissue survival via Diap1 and restricting overgrowth by arresting growth at final size in Drosophila imaginal discs.