Nicholas Arpaia

Engineered probiotics for tumor-targeted combination chemoimmunotherapy

This paper develops a bacterial platform that combines enzyme/prodrug chemotherapy and immunotherapy to enhance antitumor responses with improved safety in a murine tumor model.

Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy

This study shows engineered E. coli expressing CXCL13 enhances bladder cancer immunotherapy when combined with PD-1 blockade by promoting tumor-specific antibody responses.

Temperate phages enhance host fitness via RNA-guided flagellar remodeling

This study shows that temperate phages enhance bacterial fitness by remodeling flagella via RNA-guided transcription factors, improving motility and immune evasion.

An amphiregulin reporter mouse enables transcriptional and clonal expansion analysis of reparative lung Treg cells

The paper develops an Areg reporter mouse to study Treg cell transcriptional and clonal expansion in lung repair, identifying 4-1BB agonism as a novel reparative mechanism.

Heparan sulfate regulates amphiregulin signaling towards reparative lung mesenchymal cells during influenza A infection

This study shows heparan sulfate is essential for Areg signaling in lung mesenchymal cells during influenza A infection, affecting reparative responses.

Probiotic neoantigen delivery vectors for precision cancer immunotherapy

This study engineers probiotic E. coli to deliver neoantigen peptides, enhancing T cell immunity and reducing tumor growth in mice.

A programmable probiotic encapsulation system enhances therapeutic delivery in vivo

This paper develops a programmable probiotic encapsulation system using synthetic biology to enhance therapeutic delivery in mice by controlling bacterial immunogenicity and survivability.

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

The paper designs a probiotic platform to deliver checkpoint blockade nanobodies to tumors using a controlled lysing mechanism for therapeutic release.

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

This paper demonstrates that engineered bacteria can deliver immunotherapeutic payloads to induce durable tumor regression and systemic antitumor immunity.